And if you dont know how to deal with it, then this post is what you need.
you might find several methods in this post written byMiniTool.
Microsoft Security Essentials doesnt exist on Windows 10 anymore and it is replaced by Windows Defender.

If this problem continues, contact your System Administrator.
Error Code: 0x80070426.
Step 3: Typecontrol panelin thesearchbox and then hit the best match one.

Step 4: Navigate toPrograms>Programs & Features>Uninstall a Program, and then right-clickMicrosoft Essentialsto chooseUninstall.
Step 5: reset your box and then navigate toSettings>Update & Security>Windows Security.
Step 6: ClickVirus & threat protectionunderProtection areasin the right panel to openWindows Security.
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Step 7: ClickManage settingsunderVirus & threat protection settingsand then confirm thatReal-time protectionis on.
With this method, you might run Windows Defender normally.
Here is the tutorial:
Step 1: ClickStartand then clickSettings.
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Step 2: ChooseUpdate & Securityand then clickTroubleshootin the left panel.
Step 3: ClickWindows Updatein the right panel and then clickRun the troubleshooter.
Receive “an error occurred while troubleshooting” message when using Windows Troubleshooters to fix some issues?
Here are 8 helpful ways to fix it.
Step 1: Typecmdin thesearchbox and then right-clickCommand Promptto chooseRun as administrator.
Step 2: Typesfc /scannowin theCommand Promptwindow and then press theEnterkey.
Step 3: Wait for Windows to detect corrupt system files and then repair them.
Step 4: Reboot your rig and then test whether the error still persists.
Step 1: OpenCommand Promptas administrator as mentioned above.
Have you run into the potential Windows Update Database error detected problem?
Try the instructions in this post to fix it.