It will show you multiple useful methods to fix this error.
Hope it can be useful to you.
Why is that happening?

It may occur after updating the system or installing third-party apps without an official firmware.
Sometimes this error happens because of malware infection.
Right now, you’ve got the option to follow the instructions below to fix this error.

Step 2: Navigate to this path:HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\System.
If you cant find the mentioned key, go to this path:HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies.
Right-clickPoliciesand chooseNew > Key.
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Name the new key asSystem.
Step 3: Now, findDisableTaskMgron the right side and double-click it to open itsProperties.
Name this DWORD asDisableTaskMgr.

Step 4: Set your desiredValue dataand clickOKto save changes.
Keep in mind that value1means disabling Task Manager and value0means enabling Task Manager.
Step 1: Press theWinkey +Ikey, clickUpdate & Securityand then clickWindows Updatefrom the left side.

Step 2: ClickCheck for updatesfrom the right side.
If there are any available updates, they will be downloaded and installed automatically.
Step 3: Reboot your rig.
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Now, you should fix Ctrl Alt Del not working successfully.
Do this job with Windows Defender or another third-party antivirus.
Here is a quick guide on how to do that with Windows Defender.

Troubled by Windows Defender not turning on?
Here are full solutions to repair Windows Defender in Windows 11/10/8/7 and the best way for PC protection.
Step 1: Press theWinkey +Ikey to open theWindows Settingswindow.
Step 2: ClickUpdate & Securityand click theWindows Defenderoption from the left side.
Step 3: Click theOpen Windows Defender Security Centerbutton from the right side.
Step 4: In the pop-up window, clickVirus & threat protection.
Step 5: ClickAdvanced scannext to theQuick scanbutton.
Step 6: CheckFull scanand then clickScan now.
Windows Defender will start to scan your box and report any findings to you.
After that, remove the viruses or malware according to the removal instructions offered by your antivirus program.
Next, find out if the error is gone.
Solution 4: Check Your Keyboard
you could see if your keyboard is working correctly.
Here are some options:
1.Check your Bluetooth keyboard.
look to see if it is connected properly to your system and all other keys are working properly.
2.Perform a reset of the keyboard connection.
Plug out the keyboard, turn off the computer and take out the power cable.
Wait for a few minutes.
Turn on the computer and then plug in the keyboard.
3.Reinstall your keyboard drivers.
The following part will show you how to reinstall a keyboard driver.
Step 1: Right-click theStartmenu and chooseDevice Manager.
Step 2: Click to expandKeyboards, right-click your keyboard and chooseUninstall equipment.
Step 3: reboot your PC.
It will attempt to reinstall the driver.
Step 1: Press theWinkey +Rkey together to open theRundialog box.
Next, inputmsconfigand pressEnterto open theSystem Configurationwindow.
Step 2: Switch to theServicestab, checkHide all Microsoft servicesand click theDisable allbutton.
Step 3: Switch to theStartuptab and clickOpen Task Manager.
Step 4: tap the startup applications one by one and clickDisableto disable all of them.
Step 5: Go back to theSystem Configurationwindow and clickApplyandOK.
Step 6: power cycle your box.
see if the error reappears.
If you are experiencing this issue, try the methods mentioned above.