The option in tweaks becomes inaccessible.
After you change it, the screen still runs at the original resolution.
What has been changed is the size of the images and text.

This post introduces how to fix the display resolution greyed out issue on Windows 11/10.
you might find solutions in this post.
Here are the steps.
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Step 1: Press theWin + Ikeys to open yourSettingsand chooseSystem>Display.
Step 3: After restarting your PC, you might see if this error disappears.
It is a simple way.

The operations are as follows.
Step 1: Right-press theStartbutton and chooseWindows PowerShell (Admin).
Step 2: When prompted by UAC, click onYesto continue.

Step 3: Inputsfc /scannowin the window and pressEnter.
It will take some time.
Wait for the process to complete.
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If there are other instructions, follow the on-screen orders to finish the repair process.
It will eliminate any system errors or controls that may be affecting your display scaling.
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Here are the steps to reset your gear.
Step 1: Right-choose theStartbutton and chooseSettingsto open it.
Step 2: In tweaks, select theUpdate & Securityoption at the bottom.
Step 3: In the left pane, choose theRecoveryoption.
Step 4: In the right pane, under theReset this PC, press theGet startedbutton.
When the window pops up, select theKeep my filesoption.
Here are the main steps for you.
Step 1: Open yourSettings, and chooseSystem>Display.
Step 2: In the right pane, underScale and layout, there is a recommended size for you.
If you think it is not suitable, you could click theAdvanced scaling parameters.
Once you completed all the steps above, the display scaling is set successfully.
Go back to the desktop to see if this size is suitable for you.
How to reset display controls Windows 10?
Are you troubled by this issue?
This post shows the step-by-step guide.
Wrapping Things Up
Display scaling is important for you when using the computer.
If the a custom scale factor is set error persists, you cannot change the scaling size yourself.
Hope that works for you.