It will show you two main reasons for this problem.
In addition, it will show you some methods to fix this issue.
Now you’re able to get these methods fromMiniTool.

Malwarebytes is a powerful antivirus scanner that has a large database.
However, there are some problems with Malwarebytes.
Sometimes it wont open at all on Windows and even wont show you an fault signal.

Related article:Is Antivirus Necessary for Windows 10/8/7?
Get the Answer Now!
Causes of Malwarebytes Not Opening on Windows
You may wonder why Malwarebytes wont open.

Malwarebytes may not open on your machine for a number of reasons.
The reasons may be serious or small, and it is important for you to take immediate action.
Thus, Malwarebytes wont open because of malware.

you oughta try renaming mbam.exe executable to fix this issue.
The corrupted user account can prevent you from using many programs, including Malwarebytes.
In this case, you oughta try switching to a different user profile.
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Right now, you’ve got the option to try renaming Malwarebytes executable to fix this problem.
Step 4: make a run at run Malwarebytes and see if it opens.
Click theScanoption from the home screen of the tool to scan for viruses.

Step 6: power cycle your rig after finishing the scanning process.
This is the safest and longest method you should try.
Step 2: Retrieve your ID and Key with one of the locations in the registry presented below.

If you want to continue using Premium version after uninstalling, follow the instructions carefully.
Step 3: OpenMBAMand then openMy Account.
FindSettingsand then navigate toAdvanced options.

Uncheck theEnable self-protection moduleoption.
Step 4: Turn off MBAM and download the mbam-clean.exe tool from Malwarebytes.
Close all open programs and turn off other security tools temporarily.

Step 5: execute the mbam-clean.exe tool and then follow the instructions displayed on the screen.
power cycle your gear when a prompt says you should do so.
Step 7: UncheckTrial.

Click theActivationbutton after you launch the program.
Step 8: slide in your ID and Key you retrieved from the registry.
Your license should be activated automatically.
Now it’s possible for you to use Malwarebytes Anti-Malware Premium.
Hope the error about Real-Time Protection will go away.
Check to see if the Malwarebytes not opening on Windows issue is gone.
When you use other programs, this issue can manifest in different ways.
Your user account is usually related to your personal files and they can be transferred easily.
Step 1: Press theWindowskey andRkey at the same time to open theRundialog box.
Typecmdin the dialog box and press theCtrl + Shift + Enterkeys combination to openCommand Promptas administrator.
Step 2: key in the commandcontrol userpasswords2and pressEnterto navigate to theUser Accounts.
Step 3: Click theAdd…button and follow the instructions displayed on the screen.
Select theSign in without a Microsoft accountoption to create a non-Microsoft account.
Step 4: ClickNextand then clickLocal accountin the next window to confirm your choice.
Fill out other information.
Step 6: get in to the account you have just created.
Right now, it’s possible for you to check to see if the Malwarebytes not responding issue disappears.
Microsoft made it harder to create Windows 10 local accounts.
Read this post to get more information and learn how to sign in with a local account.
I met the Malwarebytes not opening on Windows issue before.
you could alsoclone OS from HDD to SSDwith theClone Disktool of it.
Step 1: Choose Your Backup Source
1.After installing, launch MiniTool ShadowMaker.
2.ClickConnectin theLocalmodule to get its main interface.
3.Click theBackuptab in the main page.
Step 2: Select a Destination to keep your Backup Files
1.Click theDestinationtab in the main page.
2.Choose a destination where you want to stash your backup files.
There are 5 available destination paths for you to choose Administrator,Libraries,Computer,NetworkandShared.
ClickOKto back to the main page.
Step 3: Perform Backup Operation
1.ClickBackup nowto execute the backup operation at once.
2.ClickYesto confirm that you want to do the backup operation now.
you’re free to also checkShut down the computer when all the running backup tasks are finished.
With it, it’s possible for you to sync files and folders.
Right now, free get this powerful program.
In addition, it also recommends a piece of powerful software MiniTool ShadowMaker to you.
With it, you back up your data and sync your data to keep your data safe.