Thumbs.db files are database files, generated when you view folders in Thumbnail view.
After Windows Vista, a thumbnail cache is centralizedly stored at%LocalAppData% \Microsoft\Windows\Explorer.
It helps you to quickly reuse files and improve the computers performance.
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People tend to delete thumbs.db when it forms a huge folder structure without any content.
But they are unable to delete thumbs.db because the file is in use.
Step 1: PressWin + Eto open File Explorer.
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Step 2: ChooseViewon the top toolbar, then hit theOptionschoice to fire up the Folder Options window.
Step 3: UncheckDisplay file icon on thumbnailsandHide protected operating system files (Recommended)under the View tab.
Step 4: ClickApplyandOKto save the changes.
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You should find the thumbs.db file and change its extension to.dat, then make a run at delete it.
This post tells how toshow hidden filesin detail.
Step 1: PressWin + Rto kick off the Run window.
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Step 3: Navigate toUser Configuration>Administrative Templates>Windows Components>File Explorer.
Step 4: Double-hit the policy to modify the policy.
ChooseEnablein the following window, then clickApplyandOKto confirm the change.
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Clean boot will boot your machine with a minimal set of drives and startup programs.
you’re able to take a stab at delete some stubborn files in a clean boot easily.
Step 2: Typemsconfigand hitEnterto open System Configuration.
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Step 3: Under theServicestab, tickHide all Microsoft servicesand clickDisable all.
Step 4: Turn to theStartuptab to selectOpen Task Manager.
Step 5: you should probably disable all the programs listed here.
After this, closeTask Manager.
Step 6: Return to the System Configuration window and clickOKto confirm.
your setup will be in a clean boot environment after restarting.
Different situations need different solutions.
Hope you could find one method that can fix your problem.