If yes, thisMiniToolpost is where you gotta go.
Here are two specific cases of the error and relevant solutions.
Check Whether Your CPU Supports AVX2
Marvel Spider-Man 2 is a newly released welcome game.

Here is an easy guide to dig out the specific information about your processor.
PressWin + Rto launch the Run window.
Typemsinfo32into the dialog and pressEnterto launch the System Information window.
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On the right pane, it’s possible for you to find detailed information about your processor.
Go to the official website of your processor and check the supported technologies of the current CPU.
AVX2 will be listed if it is supported by your processor.
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Read this post to find the specific location and file protection methods.
Fortunately, you’re able to handle this glitch by downloading the AVX2 mod on your rig.
#1.

Download the AVX2 Mod
Step 1. you’re able to download the AVX2 mod from theNexus Mods website.
With the AVX2 mod, you are able to play Marvel Spider-Man 2 with the current CPU.
Change to theFILEStab and clickMANUAL DOWNLOADto download the compressed folder.
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C:\Users\username\Documents\Marvels Spider-Man 2
Step 4.
Then, you gotta launch the game via theSpider-Man2-AVX2-Launcherfile.
How can you sort out the Schedule I stuck on loading issue?
you’re free to read this post to get some useful information.
In this case, how can you fix this error?
Here are two methods for you.
#1.
To fix Spider-Man 2 CPU Feature AVX2 Not Present error, follow the next steps.
Right-tap on theWindowsicon and chooseDevice Manager.
Expand theProcessoroption where are usually several options.
Right-punch them one by one and chooseUninstalldevice.
Afterward, cycle your gear to let it download the latest CPU drivers automatically.
#2. you might check via BIOS and enable it if necessary.
Save the change and exit BIOS.
How can you patch up the Split Fiction fatal error on Windows?
This post gives four useful solutions in detail.
Hope here is some useful information for you.